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The deficiency of this experiment is that not only hyperuricemia but also numerous distinctive systemic diseases including diabetes mellitus and cardiovascular disease are closely related to periodontitis, in which specific illnesses are regarded as potential covariates by researchers ( The effect of periodontal pathogens on salivary or plasma UA levels and the hyperuricemia may promote the growth and reproduction of related periodontal pathogens P

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In vitro and animal-model studies have examined its interaction with angiogenic, nitric-oxide, and growth-factor signalling pathways relevant to soft-tissue research

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10.1016/j.neulet.2013.05.058 Neurosci