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These changes are relatively minor but significant enough to merit attention, especially for at-risk populations
STEP 1: the foundational study This trial enrolled 1,961 adults with BMI of 30 or higher (or 27 with comorbidities) and randomized them to semaglutide 2.4 mg weekly or placebo for 68 weeks
Nonetheless, the lack of heterogeneity in our meta-analyses strengthens the quality of our evidence
Its also not a known side effect of another GLP-1, tirzepatide (Mounjaro, Zepbound)
Weight loss plateau or reversal
In some cases, rapid weight gain occurred after discontinuation an indication that long-term success depends heavily on lifestyle
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