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In the same study, LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry) was used to quantify the PPP intermediates (i.e., 6PGL, R5P, and S7P) produced by the wild-type and the deletion strains exposed to H 2 O 2

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Because the analysis combined results from multiple trials rather than individual patient data, it cannot fully capture how outcomes vary between individuals

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Literature search was performed by two independent reviewers (ZG and TW)