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In the presence of TTX, -Glu-Gluelicited responses were completely blocked, indicating that global [Ca 2+ ] i increases resulted from the excitatory action of -Glu-Glu via NMDAr activation and subsequent AMPAr and NMDAr activation likely by endogenous glutamate release

Hansen D, Rasmussen K, Danielsen H, Meyer-Hofmann H, Bacevicius E, Lauridsen TG, Madsen JK, Tougaard BG, Marckmann P, Thye-Roenn P, Nielsen JE, Kreiner S, Brandi L

Abstract Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2 ) and therefore allowing chemical energy-transfer for aerobic metabolism

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The impact of amyloid burden and APOE on rates of cognitive impairment in late life depression