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Huang CY, Hsieh YL, Ju DT, Lin CC, Kuo CH, Liou YF, Ho TJ, Tsai CH, Tsai FJ, Lin JY (2015) Attenuation of magnesium sulfate on CoCl-induced cell death by activating ERK1/2/MAPK and inhibiting HIF-1 via mitochondrial apoptotic signaling suppression in a neuronal cell line

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316 Another Phase 2 study evaluating AXA1125 for the treatment of fatigue after COVID-19 infection has been completed, and a clinical study evaluating the safety, efficacy, and tolerability of AXA1125 in the treatment of nonalcoholic steatohepatitis (NASH) is ongoing

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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig