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Several MR studies using genome-wide association study (GWAS) data of European ancestry have established a causal effect of MDD on T2DM, confirmed by robust sensitivity analyses excluding horizontal pleiotropy, with 36.5% of the effect mediated by BMI [58,59,60]

Doubling the dose at one time significantly increases the likelihood of GI side effects without proportional benefit and is not supported by any trial data

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FGFs, especially FGF-18, act through tyrosine kinase receptors (FGFRs) to initiate downstream RASRAFMEKERK signaling, thereby enhancing MSC proliferation and early chondrocyte expansion