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10.1016/j.pnpbp.2008.10.005 43

In peptide therapy, GLP-1 analogs are used to mimic the effects of this hormone, leading to several weight loss benefits: Appetite Suppression: GLP-1 helps reduce hunger by signalling the brain to feel full

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By activating the GLP-1 receptor, retatrutide is thought to enhance insulin secretion in a glucose-dependent manner, suppress glucagon release, and reduce appetite by acting on satiety centres in the brain

Typically, treatment begins with a lower dosage and is scaled up as individuals acclimate to the side effects

These topical approaches can be used alongside systemic medications or as standalone treatments for localized allodynia