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Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cgas/sting/nf-Kb pathway

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TIMMONS, E.M., CHAKLOS, R.J., BANNISTER, T.M., & KAPLAN, H.M

Although our data do not provide a clear explanation about the mechanisms by which vitamin C potentiated the effect of MSM, they suggest that MSM, and vitamin C have common targets or work synergistically to protect cells from oxidative damage

Cell Commun Signal 14:2 Takata F, Nakagawa S, Matsumoto J, Dohgu S (2021) Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for prevention and treatment of BBB dysfunction

This combination regimen demonstrated a superior safety profile compared to immunosuppressant monotherapy, while mitigating risks of overtreatment-related adverse events such as hepatotoxicity and serious infections (240)