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The substitution at position 2 is the functionally important one: it blocks cleavage by dipeptidyl peptidase-4, the protease that degrades native GRF within minutes

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Hormone replacement therapy Hormone replacement therapy (HRT) refers to treatments that aim to relieve the common symptoms of menopause and the long-term biological changes, such as bone loss, that occur after menopause due to declining levels of the hormones estrogen and progesterone in a womans body

2014;9(8):e104948

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Biochim Biophys Acta 1833(6):14981510