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For example, (-)-epicatechin (Epi) and its derivatives act as GPER agonists, activating pathways such as nitric oxide (NO) production, whereas perfluorinated compounds (PFCs) alter GPER conformation, impacting its signaling [17, 18]

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Additionally, it addresses redness associated with conditions like acne and rosacea, while promoting mild anti-aging effects through improved skin texture and collagen production