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& Wortmann, S
Elevation of the transcript levels of PPAR- leads to an increase in the amount of oxidative enzymes in peroxisomes, which promotes -oxidation of fatty acids, bile acid and cholesterol metabolism (77)
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These observations can then be interrogated in advanced human-relevant platforms, including patient-derived iPSC-based cardiac organoids and microfluidic organ-on-a-chip systems, to dissect ferroptosis-associated signaling networks in a controlled environment
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A., Pyae Phyo, A
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