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(And there would similarly be no reason not to take it with Femara, the mechanisms of Clomid and Femara are different but neither should involve anything ALC related.) Heres another study in PCOS of acetyl-l-cysteine (a different amino acid, but still an acetyl group donor) and Clomid with similar improvements in ovulation rate but not striking differences in the other measured outcomes

The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]

This separation can be seen in Figure 4 along with the separation of C5-valeryl-L-carnitine, C5-isovaleryl-L-carnitine, and 2-methyl-butyryl-L-carnitine

The discovery of LSECs as the 'gatekeepers' is fascinating