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The heart rate increase is likely due to direct stimulation of GLP-1 and glucagon receptors in the heart, while the blood pressure reduction may be caused by other systemic effects like vasodilation and increased sodium excretion from the kidneys

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Clinical study participants Forty-five subjects were screened for the trial and 44 (48% females) were enrolled (1 screening failure due to higher BMI, see Figure 3) between March and July 2023

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