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NDUFA5 is a part of complex I of the ETC and its mutations may contribute to ASD [86]

Hrudka, J

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Although fibrous astrocytes are less frequently associated with classical tripartite synapses, they modulate axonal conduction and participate in axoglial interactions that share functional similarities with tripartite arrangements, thereby supporting neuronal communication and structural integrity

But this also means the drug accumulates in the body over multiple doses before reaching steady state