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It is worth noting that, consistent with experience across the GLP-1/GIP class, weight loss in people with type 2 diabetes may be somewhat smaller in magnitude compared with those with obesity alone

Superior Muscle Preservation One of the most common concerns with rapid weight loss is the loss of lean tissue alongside fat

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Key drug interactions to be aware of include: Diuretics: May increase the risk of dehydration and low blood pressure Insulin or Insulin Secretagogues: May increase the risk of hypoglycemia (low blood sugar) Drugs that Interfere with Metformin Clearance: Such as ranolazine, vandetanib, dolutegravir and cimetidine Synjardy and Insulin Synjardy can be used with insulin but this combination may increase the risk of low blood sugar

PMID 12490284

Front Cell Infect Microbiol (2020) 10:63