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METHOD Data from a quality follow-up of Swedish patients (n=25,824) at specified time points was analysed

Fatigue that persists beyond three to four weeks at the starting dose warrants investigation

The study found that the use of medroxyprogesterone acetate for one year or more is associated with a 5.6-fold increase in risk

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The comparisons that follow use mechanism, clinical or preclinical trial data, dosing conventions, and regulatory status to give clinicians and patients a usable decision framework rather than marketing language

Staying hydrated, eating smaller meals, and avoiding high-fat foods can reduce the severity of digestive discomfort during the adjustment period