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Most appear in preclinical PubMed studies, which doesnt make them approved for human use

But ultimately, they need to be studied more

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Comparing the glutathione-scaffold site among a variety of other members of the thioredoxin superfamily also provides an explanation for their disulfide substrate preferences, for example, why glutaredoxins prefer GSSR in contrast to thioredoxins lacking most of the relevant residues (Fig