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Islet exposure to cytokines triggers nuclear factor B (NFB) induction of inducible nitric oxide synthase (iNOS), which increases NO formation in the beta-cell (87)

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These peptides can either promote hormone release, regulate receptors, or nourish endocrine glands to help bring balance

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When both secretagogues were present together, the calculated response increased to around 54-fold above saline, which was on the order of 1015% higher than GHRP-2 alone