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Individuals receiving therapeutic B12 injections or taking high-dose oral supplements without medical supervision face the greatest risk of very high levels
Proc Natl Acad Sci USA 70 , 22812285 (1973)
miR-16 and miR-223 are also identified as targets to distinguish patients with early RA from healthy individuals ( Most of the aberrant miRNA levels can alter the secretion of inflammatory cytokines or MMPs, further affecting the procession of RA
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PMID 18177777
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