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C5a can activate pro-inflammatory signaling pathways such as NF-B and upregulate the expression of adhesion molecules on endothelial cells or macrophages, thereby promoting the adhesion of leukocytes to the endothelium and the recruitment of inflammatory cells (120)

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There was a significant reduction in the arthritis score with a significantly decreased secretion of pro-inflammatory cytokines (TNF and IL-6) and an increased concentration of IL-10, an anti-inflammatory cytokine (Amdekar et al., 2011)

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