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[1] [2] This warning applies to several long-acting GLP-1 receptor agonists, including semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and exenatide extended-release (BYDUREON BCise)

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While demonstrating biological plausibility and mechanisms, in vitro conditions poorly replicate complex in vivo environment