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The slower release of LS from F1 compared to free LS solution would be credited to the high transition temperate of Span 60 that offers a more rigid and less permeable vesicle structure, leading to a delayed rate of drug release 57

For progressive forms, such as secondary progressive MS (SPMS) and primary progressive MS (PPMS), therapeutic options are limited compared to relapsingremitting MS (RRMS) [141]

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