Several studies provide strong support for ascorbates ROS-scavenging abilities
Clinical trials and post-marketing monitoring continue to review long-term safety data
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In a 12-week, placebo-controlled, dose-ranging study of the effects of fezolinetant on menopausal VMS, most women who received fezolinetant experienced a 50 to 60% reduction in hot flush frequency and an improvement in menopause-specific quality of life at weeks 4 and 12 (Figure 3)
Any disruption of the aforementioned processes can cause placental dysfunction, which in turn could lead to placental abnormalities, implying the dysregulation of diverse molecular pathways, thus inducing a variety of disorders during pregnancy, including failed abortion, spontaneous abortion, intrauterine growth restriction (IUGR), oxidative stress, excessive accumulation of dysfunctional adipose tissue related to insulin resistance, diabetes, and other metabolic disorders, gestational hypertension, and pre-eclampsia [5,6,7,8]
