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DDAH is upregulated in IPF, leading to decreased ADMA levels and increased NOS2 activity, thereby enhancing NO production and contributing to fibrotic progression [81]

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[The impact of carnitine on serum ammonia concentration and lipid metabolism in patients with alcoholic liver cirrhosis]

Both dethymoquinonated and regular volatile oil from black seed lowered arterial BP and HR in rats, with the CV depressant effects potentially mediated by central mechanisms involving activation of 5-hydroxytryptaminergic and muscarinic pathways (425, 426)

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