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Although substantial weight loss can reduce pathological joint loading and systemic inflammation, the direct pharmacological effects on synovial fibroblastsattenuating their inflammatory signalling and fibrotic activation may offer an additional, disease-modifying and analgesic mechanism that targets the local synovial environment, driving pain and structural progression
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Injection site rotation : Regardless of timing, rotating between the abdomen, thigh, and upper arm is recommended to minimise local reactions, in line with SmPC guidance for comparable weekly injectables
Entchev, E
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