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Individuals with obesity and type 2 diabetes have higher baseline rates of depression and mental health conditions compared with the general population, making it difficult to determine whether reported symptoms represent medication effects or underlying psychiatric comorbidity

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Further analysis showed that tryptamine levels increased markedly during this period, whereas tryptophan levels initially decreased before rising again (Fig

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1.9.1 Role of the gut neuroendocrine system in appetite regulation Several neural, hormonal and psychological factors control the complex process known as appetite