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Considering pathophysiological mechanisms insulin sensitizing drugs counteracting insulin resistance should be considered as first choice

Each datapoint represents one patient

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Combination studies with semaglutide consistently outperformed the GLP-1 drug on its own, which is the cleanest available evidence that an amylin analog adds to, rather than duplicates, incretin-based weight loss

Acknowledgements Authors wish to thank Molecular Medicine Department and also Pharmaceutical Sciences Research Center of Shiraz University of Medical Sciences

e cellular mechanism for GPR has not been exten- sively revealed, but it is believed to couple with Gssubunit and to elevate intracellular cAMP levels