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Animal studies demonstrate satellite cell activation and fusion into existing muscle fibers, supporting hyperplasia theory

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The RBC uses most of this ATP to maintain electrochemical and ion gradients across its plasma membrane

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Probiotics Antimicrob Proteins 18:26392653

Although mechanistic details are lacking, two scenarios to explain these observations are favored: Metabolically active intracellular parasites consume oxygen and decrease intracellular pH, both of which promote sickling of AS red cells