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A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA

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Lower melatonin doses (1.5 mg/kg/day) in a mouse model of AD (Tg2576) showed no significant modification of brain APP immunoreactivity compared to non-treated animals [165], emphasizing the need to determine efficacious doses

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