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M2-like (or homeostatic) states help preserve neurons by removing extracellular -synuclein fibrils, releasing neurotrophic factors like BDNF (brain-derived neurotrophic factor) and GDNF (glial cell linederived neurotrophic factor), encouraging synaptic repair, boosting glutamate uptake via EAAT2, and creating anti-inflammatory cytokines like IL-10 and TGF-
Safe prescribing relies on BNF monograph checks, MHRA SmPC review, prominent recording of G6PD status in medical records, and pharmacist involvement at the point of dispensing
This article is for informational purposes only and does not constitute legal advice.
a higher-concentration serum used sparingly may provide better value than a lower-concentration cream that requires larger amounts for effectiveness