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Doses of semaglutide ranging from 0.1-1.6 mg resulted in a 2.1%, 7.0%, 13.0%, 37.5%, 51.2%, and 63.6% respective dose-dependent increases in the proportion of patients that achieved a 5%, or greater, reduction in weight loss

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The tirzepatide has substantially cleared, but the semaglutide has not yet reached full steady-state concentration

While there is no definitive evidence that tirzepatide causes MTC in humans, the FDA requires a boxed warning, and the medication should not be used in patients with these risk factors

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But doctors may sometimes prescribe both Mounjaro and Ozempic off-label for weight loss