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Non-alcoholic fatty liver disease does not increase dementia risk although histology data might improve risk prediction

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Preclinical studies suggest ALA may help defend neurons against oxidative stress, support synaptic function, and maintain healthy levels of glutathione, a critical antioxidant in brain cells.12 25 Importantly, ALA can cross the blood-brain barrier, making it a promising candidate for addressing conditions where oxidative stress or mitochondrial dysfunction play a role

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doi: 10.3390/ijms18112493 214 KandimallaRThirumalaVReddyPH

The second is tolerability, since gastrointestinal effects and discontinuation rates differ across candidates and are becoming a real point of differentiation, as set out in the full side-effect profile of the GLP-1 class