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The present study emulated a target trial to avoid immortal time and selection bias, chose a second-line glucose-lowering therapy as an active comparator to reduce confounding by indication, used an outcome definition based only on primary care records to minimize detection bias due to differential hospitalizations, and implemented a lag time to mitigate bias due to reverse causality

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Most patients complete 3 to 5 sessions spaced 4 to 6 weeks apart for a full skin rejuvenation course

In some embodiments, the formulation or composition has a viscosity of about 300 cP

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