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It includes positron emission tomography-magnetic resonance (PET MRI) studies of plaque inflammation (plaque 18 F-FDG and 68 Ga-DOTATATE uptake), MRI for plaque morphology and burden, as well as biomarkers, proteomics and RNA profiling, myocardial perfusion reserve and changes in carotid artery total wall volume

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Semaglutide is a once-weekly injection

While this is protective against age-related hyperfunction, it theoretically risks blunting the anabolic responses required for new synaptic formation, muscle hypertrophy, or exercise adaptation in subjects who are not already biologically aged

For me, though, the tradeoff has felt worthwhile