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Two of the children exhibited increased seizure activity as their VPA levels went down

Although energy metabolism status can also regulate intracellular ROS levels (e.g., glucose deprivation leads to a marked increase in cellular ROS) [53,54,55,56], our study demonstrated that supplementation with energy substrates such as sodium pyruvate in GGCT-knockdown cell models did not induce significant alterations in intracellular ROS levels

The enhanced potency of IGF-DES compared to native IGF-1 makes it useful for research into growth factor-mediated tissue repair