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KEGG pathway analysis of downregulated (upper panel) and upregulated (lower panel) genes in Bmal1 -KO vs

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reduced back) by the enzyme glutathione reductase using NADPH as an electron donor

Brown Norway rats that did not undergo any treatment (PQ or eye drops) were also included as a healthy untreated control group

Test compounds were administered via oral gavage to all mice groups after 1 hour of fasting

RT was done with a RevertAid H cDNA Synthesis Kit (Thermo Fisher Scientific, USA) according to manufacturers instructions using both TMV coat protein gene reverse primer ( TMV-CP rev) and an oligo-dT primer