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His pain increased and he developed additional symptoms including nausea, lethargy, decreased appetite, constipation, decreased urinary stream, and a 57 kg weight loss

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Some studies suggest a zinc deficiency is a cause of subclinical hypothyroidism, which may slow metabolism and contribute to unexplained weight gain and fatigue

Our results are in agreement with previous studies performed in bovines, where oocytes subjected to heat stress before 12 h of maturation 49 , or even in the short term at the early stage of maturation, resulted in increased Annexin-V binding and oocytes that underwent early apoptosis compared with those in the control group 51

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