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A mouse model of down syndrome trisomic for all human chromosome 21 syntenic regions

These symptoms tend to improve or disappear after a few days and are more likely to occur when dosage is increased

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However, when the structural rearrangement is the result of an unbalanced translocation, deletion, tandem duplication, or even chromothripsis, copy number changes are introduced involving the chromosomes on which the rearranged genes reside

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PMCID: PMC8085572 ) Trujillo JM, Nuffer W, Smith BA (2021) GLP-1 receptor agonists: an updated review of head-to-head clinical studies