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A ligand for TdfF has not yet been identified, but, as mentioned above, among the possible candidates for iron sources in the intracellular environment (ferritin, iron chelated to organic acids or to glutathione), only ferritin has been shown to contribute to the intracellular survival of N

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Furthermore, the AMPK/PPAR coactivator-1 (PGC1) pathway upregulates autophagy-related genes, thereby promoting autophagy and phagosome fusion in macrophages during M.tb infection [116]

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