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Additionally, systematic reviews of observational studies have found no evidence of an association between folate exposure during pregnancy and childhood asthma or allergies (80, 81)

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However, successful clinical translation will require a deeper understanding of redox thresholds across cell types, subcellular compartments, and disease stages, as well as strategies to overcome compensatory antioxidant networks and systemic toxicity associated with non-specific redox modulation

148 PatelD.RathinamM.JarvisC.MahimainathanL.HendersonG.NarasimhanM

Bibcode:2006AnRPB..57..805Z

GSH also serves as an essential electron donor to glutathione peroxidases (GPx) in the reduction of hydroperoxides 7