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Leverage tends to magnify, sometimes significantly, the effect of any increase or decrease in a funds exposure to an asset or class of assets and may cause the value of a funds shares to be volatile and sensitive to market swings

Combined with semaglutide as CagriSema, it pushed weight loss to about 22.7% at 68 weeks (REDEFINE-1)

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The plan could expose division between CMS head Mehmet Oz, who has previously praised such drugs, and health secretary Robert F Kennedy Jr, who has criticized their high cost and how they are not a substitute for a healthy lifestyle.

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