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PMID 18177721

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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

Beyond brain imaging, attention has increasingly shifted toward peripheral tissues, where accessible biopsies such as skin samples provide a minimally invasive avenue to detect hallmark proteinopathies and extend biomarker discovery beyond the CNS

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