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In a study targeting suicide attempts as the endpoint, a control group with a higher prevalence of depression and suicidal ideation might lead to outcome bias, as evidenced by the increased incidence of suicidal ideation within the control group

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For example, animal studies show mast cells in the colon release prostaglandin E2, causing pain and hypersensitivity in IBS (irritable bowel syndrome)

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Some general observations of the effects of breed on health include: Breeds with certain anatomical features can be associated with a higher risk of certain diseases