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4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

The evidence applies to symptoms of both early and late dumping syndromes, after peptic ulcer, bariatric and cancer surgeries

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It regulates temperature, metabolism, and cerebral function, and is a massive contributor to energy levels and the bodys ability to maintain a constant temperature

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These findings lend support to the hypothesis that the increase in SHBG levels induced by liraglutide might contribute per se to reduce the risk of developing the metabolic syndrome in PCOS, also considering the effect of SHBG in directly suppressing inflammation and lipid accumulation in macrophages and adipocytes [65]