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In ischemic wound models, TNF- levels dropped in GHK-Cu treated tissue compared to controls

Both GIPR co-agonism (as in tirzepatide) and GIPR antagonism (as in MariTide, a bispecific hybrid molecule comprising two GLP-1R agonist peptides conjugated to a monoclonal anti-GIPR antagonistic antibody) are effective in treating people living with obesity 2,3,22

This research described MOTS-c as a mitochondrial-derived peptide that regulates insulin sensitivity and metabolic homeostasis

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