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In a major clinical trial, people taking the highest dose lost about 11% of their body weight over 72 weeks

These medications have gained immense popularity for their effectiveness in managing weight and improving glycemic control

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Analysts are projecting those numbers to grow significantly in the coming years, with Mounjaro having potential to compete for diabetes market leadership

How these medications cause weight loss when combined is still somewhat of a mystery, but experts theorize that the combo touches the brains reward centers: Bupropion affects the pathways of two neurotransmitters, dopamine and norepinephrine, which are used in brain areas that process appetite and reward, and naltrexone tends to boost and reinforce this effect, Maselli says

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