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Common Overlapping Diagnoses in POTS Patients Patients with POTS often experience a range of other disorders, reflecting the interconnectedness of autonomic dysfunction, systemic inflammation, and nervous system imbalances

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The predicted translation products were aligned using the R package Biostrings v2.52.0, with BLOSUM100 as the score matrix, and alternative aa sequences were defined by comparing the predicted aa sequence of each mRNA isoform with that of the reference (canonical) mRNA, taking as reference the longest and/or most prevalent mRNA isoform in islets (alternative sequence generation filter)