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Food intake in animal studies remained unchanged despite the compound producing significant fat loss

In addition, in research on aging-related muscle atrophy (sarcopenia), it can promote muscle cell proliferation and differentiation, reduce muscle cell apoptosis, and enhance muscle strength and endurance by activating the SIRT1 signaling pathway

The dysfunction of the gut-liver axis significantly increases the risk of engineered live bacteria translocation [213]

This escalation should only occur if the lower dose is well-tolerated and additional benefit is needed to achieve treatment goals