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While stiffness had no effect on MC proliferation in the presence of COL IV and FN, we observed a higher proportion of BrdU-positive iMCs when exposed to stiff COL I-coated substrates, indicating a synergistic effect of COL I and stiffness on MC proliferation (Fig

Weight maintenance is a long game, and the data suggests that the risk of regain extends well beyond the initial transition period

Steroids are addressing inflammation

The deterioration of CKD is influenced by multiple factors, such as a reduction in parenchymal cells, persistent chronic inflammation, tissue fibrosis, and a decrease in the kidneys ability to self-repair

However, its role is more about optimizing the function of existing cells and promoting healthy tissue remodeling, rather than direct "stem cell activation" in the broad sense

Binding of the IgG complex to FcR requires translocation of the receptor to lipid rafts which is dependent on its palmitoylation at Cys208 (177, 178)