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B12 is used to initially treat B12 deficiency and anaemia

ScRNA-seq analysis revealed that patients with stable disease harbored a higher proportion of FLAD1 + tumor cells compared to those with partial response, although this difference did not reach statistical significance ( P = 0.11, Fig

While the supplements have a milder effect than the drug, they are an excellent choice for those who: Do not want to go on the drug Discontinued the drug due to side effects Want to buffer the side effects of the drug Nutrients that Stimulate GLP-1 Production Probiotic Species: Akkermansia Mucinophilia generates propionate, a short chain fatty acid, and a protein called P9, both of which induce GLP-1 production Clostridium butyricum produces butyrate, which stimulates GLP-1 Bifidobacterium infantis Produces acetate and lactate, which feed the two strains mentioned above, naturally boosting GLP-1 production Bifidobacterium longum increases short chain fatty acids and normalizes leptin, the satiety hormone Lactobacillus plantarum increases short chain fatty acids, normalizes leptin, and decreases inflammation Berberine: Like GLP-1 medications, Berberine has a multitude of metabolic benefits

Long-term safety data remain limited

Data availability All data needed to evaluate the conclusions in the paper are present in the Source Data file